4^th European Congress on
Pharmaceutical Sciences

Biography:

S Angala parameswari has expertise in Analytical method development and validation and passion in improving interpretation of analytical data. She has 12 years of experience in research, evaluation, teaching and guidance of students in education institutions. She honoured as Best teacher in 2015 by AKSHARA KEERTHI PATTABHADRULA SAMKSHEMA SEVA SAMITHI, Nellore. She has published 25 above research publication and attended 15 above conferences national and international levels. She has guided 44 PG students and 25 UG student and 4 Ph.D students during her professional life. She was a life member in APTI.

Abstract:

A simple, accurate & precise method was developed for the simultaneous estimation of Darunavir (DAR), Cobicistat (COB), Emtricitabine (EMT) and Tenofovir alafenamide (TEN) in their bulk and pharmaceutical formulation. Combination of DAR, COB, EMT and TEN is a first ever protease-inhibitor-based single-tablet regimen with DAR being a Protease Inhibitor(PI), COB a pharmacokinetic enhancer of DAR and EMT, TEN belonging to Nucleoside reverse transcriptase inhibitors (NRTI) is recently approved by U.S. Food & Drug Administration (US FDA, 2018) and European Medical Agency (EMEA, 2018). Literature review has revealed that no analytical method has been published. This study also deals with stability studies for developing a degradation pathway and to isolate the impurities which are likely to be present. Chromatogram was run through Agilent C₁₈ (150 x 4.6 mm, 5m) column. Mobile phase containing 0.1% Ortho Phosphoric acid (OPA) (pH 2.4) and Acetonitrile in the ratio of 55:45 was pumped through the column at a flow rate of 0.75ml/min while the temperature was maintained at 30°C. The optimized wavelength for the combination was 245 nm. Retention time of DAR, COB, EMT, and TEN were found to be 3.988 min, 3.147 min, 2.205 min and 2.616min respectively. The linearity range for the method was found to be 200-1200µg/ml for DAR, 37.5-225 µg/ml for COB, 50-300 µg/ml for EMT and 2.5-15 µg/ml for TEN. The method was validated according to ICH guidelines. Forced Degradation studies were performed on different conditions and the % drug degraded was found to be within limits.  Conclusion: The developed and validated method can be routinely used for the analysis of pharmaceutical formulation.

Biography:

Opeyemi O. Ayodele is a lecturer of Biochemistry in Biological Sciences department of Mountain Top University, Nigeria. Her research interests include Phytomedicine and drug discovery, Diabetic, antioxidant, blood coagulation and protein studies. She has been privileged to attend several conferences and workshops, local and international, and was a recipient of Global Travel award by Bill and Melinda Gate foundation to attend Keystone symposia on Diabetes at Keystone, Colorado, USA

Abstract:

Drug therapy problem (DTP) is any unwanted incident related to medication therapy that actually or potentially affects the desired goals of treatment. Heart failure (HF) patients are more likely to experience DTP owing to multiple prescriptions and comorbidities. Despite the serious negative impact of DTP on treatment outcomes, there is a dearth of study on DTP among HF patients in Ethiopia.

Biography:

Rajaa Seghiri has her expertise in evaluation and passion in Industrial Engineering, Food Science and Green Chemistry. She is interested mainly in valorization of algae in various industrial and research sectors for interest in food security. Her open and contextual evaluation studies based on nutritional, chemical, techno functional and biological verifying that creates new path ways for improving wellbeing. She has a significant experience in research, evaluation and teaching both in university and education institutions.

Abstract:

The present study aimed to characterize the nutraceutical properties and the antimicrobial e.ect of Moroccan Spirulina (Arthrospira platensis). e nutritional composition was evaluated, including water content, crude protein, total carbohydrates, lipids, phenolic composition, macro- and micromineral content, fiber content, and energy value. Then, the microbiological analysis and antioxidant activity were measured. The antimicrobial activity was evaluated using the minimum inhibitory concentration method on bacteria and fungi. Moroccan Spirulina contained a large amount of protein (76.65 ± 0.15%), followed by carbohydrates (6.46 ± 0.32%), minerals (20.91 ± 0.88%), crude fiber (4.07 ± 1.42%), lipids (2.45 ± 0.82%), ash (14.56 ± 0.74), and twenty phenolic acids being identified and quantified. Moreover, flavonoid and phenolic contents were present at 15.60 ± 2.74 mg RE/g dw and 4.19 ± 0.21 mg GAE/g dw, respectively. Microbiological risk assessment indicated that this product is safe to be consumed as a human food product. e antioxidant activity was higher in the methanolic fraction (23 mg TE/g dw) (DPPH).

Biography:

Dr has her expertise in evaluation and passion in Industrial Engineering, Food Science and Green Chemistry. She is interested mainly in valorization of algae in various industrial and research sectors for interest in food security. Her open and contextual evaluation studies based on nutritional, chemical, techno functional and biological verifying that creates new path ways for improving well being.  She has a significant experience in research, evaluation and teaching both in university and education institutions.

Abstract:

In Morocco, like in many developing countries, people usually tend to turn to unconventional therapies. An ethnophycological survey was realized to inventory seaweeds used in complementary Moroccan medicine. One hundred ninety-one (191) consumers and thirty-one (31) traditional healers were interviewed on seaweed food-related diseases using standardized questionnaires. The survey was conducted in some cities in Morocco. After gathering all the information, the data obtained were analyzed and summarized. The investigation has displayed emerging phycotherapy in Morocco. Consumers’ knowledge about seaweeds is complex and various. Yet, most of them are convinced of their nutraceutical benefits for a healthy lifestyle. The healers strongly support the reliability of their recommendations in treating health problems according to what the literature shows. The present study has made a contribution in giving a clear picture of the status quo of dietary seaweeds therapies in Morocco, which is revealed as an emerging practice needed to renovate pharmacopeia. Therefore, it has allowed us to list some seaweed that haven’t been considered in any scientific investigation before, which will be subject afterward to pharmacological tests to prove the claimed uses.

Biography:

Abstract:

This study compares the bone regenerative power of SIM and PRF and the combination added locally on induced bone defect and their effect on inflammatory markers.Bone specimens of the SIM group and the combination showed well observed darkly stained areas of matured bone compared to the other groups especially two-month postoperatively, the SIM/PRF group showed matured bone trabeculae surrounding bone marrow spaces which appeared densely stained with normal osteocytes lacunae. Resting and reversal lines were obviously detected in the combination group only, denoting high bone remodeling activity in this group. PRF and SIM decreased significantly the pro-inflammatory IL-1β serum levels compared to the control group, SIM loaded on PRF showed the highest statistical significant decrease in IL-1β serum concentration (P<0.001). IL-6 and TNF-α serum levels didn’t differ significantly between the control and PRF group, but showed statistical significant decrease in the SIM and SIM//PRF groups. In contrast PRF, SIM and SIM/PRF significantly increased IL-10 serum levels compared to the control group with the highest significant increase in the SIM/PRF group (P<0.001).

Biography:

Abstract:

Three different artemisinin-based combination therapies (ACTs) namely; artesunate-amodiaquine, artemether-lumefantrine and dihydroartemisinin-piperaquine (being the latest to be introduced) are concurrently being used for the treatment of falciparum malaria in Ghana. This study assessed patients’ experience, perceptions and willingness to use dihydroartemisinin-piperaquine, brand name duo-cotecxin as an alternative first line ACT for the treatment of falciparum malaria in Northern Ghana. Methods: This was a qualitative study using phenomenology approach where sixty in-depth interviews were conducted with two groups; thirty patients who were given duo-cotecxin, one group and thirty interviews with patients who were given other ACTs (artesunate-amodiaquine, artemether-lumefantrine) as another group. The interviews were conducted between August and November, 2015 Purposive sampling technique was used to select study participants. The interviews were transcribed and coded into themes using QSR NVivo 11 software for thematic content analysis. Results: All patients who used duo-cotecxin reported that the drug was very good in treating uncomplicated malaria compared to other ACTs they had used in the past. Some of the patients who used other ACTs could not complete their doses because of the side effects. However, none of the patients who used duo-cotecxin reported side effects. The findings revealed high acceptance and preference to use duo-cotecxin to treat uncomplicated malaria compared with other ACTs. All the participants were also willing to recommend duo-cotexcin to their relatives and friends to use. Conclusion: Duo-cotecxin as an alternative first line ACT for treatment of uncomplicated malaria is highly accepted; preferred and there was willingness to use it compared with other first line recommended ACTs.

Biography:

Abstract:

Organophosphorus Compound (OPC) pesticide intoxication is estimated at 3 million per year worldwide with approximately 300,000 deaths mostly in Asia pacific region. Severe organophosphorus pesticides poisoning is a major clinical problem in Bangladesh. Suspected cases of OPC poisoning were enrolled and observed for at least 96 hours. Detailed history and clinical manifestations of all enrolled cases were taken in a pre-design case record form. All admitted cases were treated with traditional antidote of Atropine and pralidoxime and other supportive treatment also given.