Shereen N Raafat1
The British University in Egypt (BUE), Egypt
Title: The effect of the PRF and Simvastatin on bone formation and post-surgical inflammation after induction of critical size bone defects in rats tibiae
Biography:
Abstract:
This study compares the bone regenerative power of SIM and PRF and the combination added locally on induced bone defect and their effect on inflammatory markers.Bone specimens of the SIM group and the combination showed well observed darkly stained areas of matured bone compared to the other groups especially two-month postoperatively, the SIM/PRF group showed matured bone trabeculae surrounding bone marrow spaces which appeared densely stained with normal osteocytes lacunae. Resting and reversal lines were obviously detected in the combination group only, denoting high bone remodeling activity in this group. PRF and SIM decreased significantly the pro-inflammatory IL-1β serum levels compared to the control group, SIM loaded on PRF showed the highest statistical significant decrease in IL-1β serum concentration (P<0.001). IL-6 and TNF-α serum levels didn’t differ significantly between the control and PRF group, but showed statistical significant decrease in the SIM and SIM//PRF groups. In contrast PRF, SIM and SIM/PRF significantly increased IL-10 serum levels compared to the control group with the highest significant increase in the SIM/PRF group (P<0.001).