Tapan Kumar Maity
Ex. Head of The Department, Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700032. India
Title: Isolation, characterization and biological evaluation of Betulinic Acid obtained from Nyctanthes arbor-tristis
Biography:
Professor Tapan Kumar Maity had completed his Bachelor, Masters and PhD from Jadavpur University, Kolkata, India. He has been in teaching as well as research for 28 years. 13 no. research scholars have been awarded PhD under his guidance and presently seven students are doing research work under his supervision. Recently two centrally funded project works have been completed successfully from his laboratory. Prof. Maity’s Lab. is dedicated to synthetic medicinal chemistry as well as plant drug research. This lab is targeting cancer/diabetes with an isolated molecule from plant extract and novel synthetic compounds. Already 92 papers have been published in the national and international journal till now. He has visited the USA, Austria, Switzerland and The Netherlands. He is the life member of the Association of Pharmaceutical Teachers of India, Indian pharmaceutical association, Indian science congress association and Society of Ethnobotany, India. He is the paper setter, evaluator and PhD thesis examiner of 18 universities in India.
Abstract:
Betulinic acid, one of the important Phyto-constituents, was isolated from ethyl acetate fraction of leaf of Nyctanthes arbor-tristis. Its structure was characterized by various spectroscopic methods such as FT-IR, NMR and Mass Spectroscopy. This isolated and identified betulinic acid is chemically lupane-type triterpenoid. In vitro antiproliferative and antioxidant activity were performed to determine its pharmacological potency. It showed significant cytotoxicity against various cancer cell lines with an IC50 of 6.53 (HepG2), 9.34 (A549), 14.92 (HL-60), 16.90 (MCF- 7), 17.07 (HCT-116), 13.27 (PC-3), and 12.55 μM (HeLa). It exhibited potent antioxidant activity with IC50 of 18.03 μg/mL. The anticancer activity of betulinic acid was evaluated against different human cancer cell lines. It had shown significant cytotoxicity against various cancer cell lines with an IC50 of 6.53 (HepG2), 9.34 (A549), 14.92 (HL-60), 16.90 (MCF-7), 17.07 (HCT-116), 13.27 (PC-3), and 12.55 μM (HeLa).